中文摘要：

目的比较研究芍药苷微乳（Pae ME）与芍药苷（Pae）对大鼠佐剂性关节炎（AA）的治疗作用。方法采用弗氏完全佐剂诱导大鼠AA模型,计数法测定多发性关节炎指数,称重法测定脾脏指数,ELISA法检测巨噬细胞分泌白介素-1（IL-1）水平和胸腺T细胞分泌白介素-2（IL-2）水平,氚标记的胸腺嘧啶核苷掺入法测定T、B淋巴细胞增殖反应,HE染色法光镜观察关节病理形态学变化等。结果 PaeME和Pae对AA大鼠多发性关节炎指数、升高的脾脏指数、升高的巨噬细胞分泌IL-1水平、降低的胸腺T细胞分泌IL-2水平、增强的T、B淋巴细胞增殖反应及关节病理形态改变等方面均有不同程度地改善作用,且Pae ME的作用强于Pae。结论 Pae和Pae ME对AA大鼠多发性关节炎和免疫功能均有明显地抑制作用,Pae ME的疗效明显优于Pae,Pae ME作为一种新剂型具有良好的开发应用前景。

英文摘要：

Objective To compare the effects of paeoniflorin microemulsion（Pae ME）and paeoniflorin（Pae） in rats with adjuvant arthritis（AA）.Methods Freund′s complete adjuvant（FCA）was used to induce AA in rats.Arthritis index and spleen index were recorded.Levels of IL-1 and IL-2 were measured by ELISA and the proliferation of T and B lymphocytes were measured by -TdR incorporation.Pathological changes in synovium of joint were observed by light microscope.Results Pae ME and Pae could alleviate the inflammation of joint at different degree and decrease the spleen index,the secretion of IL-1 and IL-2 level,T,B lymphocyte proliferation.The effect of Pae ME was better than Pae.Conclusion Pae ME and Pae can significantly inhibit the inflammation of AA rats.The curative effect of Pae ME is much better than Pae.As a new preparation form,Pae ME has good prospects for development and application.