中文摘要：

提出一种将微混合器内溶析沉淀过程与出口处高压静电喷雾干燥过程一体化以实现干燥有机药物纳米颗粒稳态、连续可控制备的方法。选用姜黄素作为研究对象,在微混合器内强化姜黄素溶析沉淀过程传质,制备得到纳米颗粒悬浮液,应用高压静电喷雾干燥法对制得的纳米悬浮液进行快速连续干燥,最终直接获得姜黄素的干燥颗粒产品。对影响干燥姜黄素产物颗粒大小和形貌的诸如流体流速和药物质量浓度等因素进行实验研究,结果发现：流体流速不但会影响微混合器出口处混合和沉淀状态,还同时会显著影响喷雾液滴的大小及分布,随着流体流速的增大产物颗粒直径显著增大、粒度分布明显变宽;电喷雾产物是悬浮液中纳米颗粒的聚集体,电喷雾大液滴将形成由较多姜黄素纳米颗粒聚集而成的大干燥颗粒,而较小的电喷雾液滴则形成了较小的姜黄素干燥颗粒;随着姜黄素质量浓度的增大,喷雾产物颗粒粒径由0.1g·L^-1时的不到100nm增大至2g·L^-1时的超过200nm,同时颗粒粒度分布也明显变宽。

英文摘要：

This paper presented a novel technology to prepare dry drug nanoparticles in a controlled manner by the integration of micromixer precipitation and electrospray drying.The curcumin nanosuspension was firstly prepared in micromixer via the anti-solvent precipitation,and then the formed nanosuspension was electrosprayed quickly and continuously to obtain dry nanoparticles.The influences of operating factors such as the flow rate and the drug initial concentration on the dry products had been investigated experimentally.The results show that flow rate and curcumin initial concentration greatly affected the size and morphology of the electrospray products.The product size and size distribution increased gradually with the flow rate.And with the increaseing of curcumin concentration,the number of nanopartilces in the suspension would confirmedly increase which in turn change the aggregation of nanoparticle in the electrosparyed droplet.Experimental data showed that product diameter increase from less than 100 nm at 0.1 g·L^-1 up to above 200 nm at 2 g·L^-1.