中文摘要：

目的：研究随着眼压增高,视乳头各形态学参数的变化趋势,以及视乳头形态学参数对压力的敏感性。方法：1选择12只健康家猫,排除各种眼疾,利用光学相干断层扫描成像技术获得正常眼压下猫视乳头形态学参数;2通过前房灌注的方法制造急性高眼压动物模型,利用光学相干断层扫描成像技术获得在40、60、80 mm Hg眼压下猫视乳头形态学参数;3利用均值和标准差分析随着眼压增高,视乳头各形态学参数的变化趋势,利用Spearman相关性分析视乳头形态学参数对压力的敏感性。结果与结论：Bruch膜开口距离与筛板深度对压力的敏感性最强,随着眼压的升高,Bruch膜开口距离逐渐增大,筛板深度逐渐减小。Bruch膜开口距离变大与筛板深度变浅对研究青光眼病程的发展有一定的指导意义。

英文摘要：

Objective To study the changes in the morphological parameters of the optic nerve head （ONH） and the sensitivity of these parameters to pressure in cats with acute high intraocular pressure. Methods Twelve healthy cats without eye diseases examined for baseline morphological parameters of the ONH using optical coherence tomography. After the baseline examinations, acute high intraocular pressure was induced in the cats by anterior chamber perfusion, and the changes in the morphological parameters of the ONH in response to intraocular pressures of 40, 60, 80 mmHg were recorded using optical coherence tomography to analyze the variation pattern of these parameters. The sensitivity of the morphological parameters of the ONH to the intraocular pressure changes were analyzed using Spearman correlation analysis. Results and conclusion With the increase of intraocular pressure, the Bruch＇s membrane opening increased progressively and the depth of the lamina cribrosa decreased gradually. The Bruch＇s membrane opening and lamina cribrosa depth were the most sensitive to intraocular pressure changes. The changes in the Bruch＇s membrane opening and lamina cribrosa depth in acute high intraocular pressure provide evidence for studying the development of the disease course of glaucoma.