中文摘要：

用骨髓有核细胞和白细胞计数的方法研究了化疗药物环磷酰胺（CTX）对小鼠骨髓的抑制作用和中药寿胎丸（FPP）的干预效应.结果表明：1）CTX有明显的骨髓抑制作用,表现在骨髓有核细胞和外周血白细胞数量显著减少（P〈0.05）;2）FPP对CTX所致的骨髓抑制有显著的干预效应,表现在明显减弱CTX骨髓抑制所造成的骨髓有核细胞和外周血白细胞数量的减少;3）白细胞着丝粒蛋白B（CenpB）的表达水平与骨髓抑制及骨髓抑制干预效应明显相关（P〈0.05）,可作为一种检测指标.

英文摘要：

Bone marrow suppression after cyclophosphamide（CTX） chemotherapy and intervention by traditional Chinese medicine（Shoutai Wan,fetus protection pill,FPP） were studied.The results are as follows： 1）CTX distinctly suppressed bone marrow,resulting in reduced counts of nucleated bone marrow cells and leukocytes（P〈0.05）.2）FPP showed marked effect against bone marrow suppression by CTX,with reduction in nucleated bone marrow cells and leukocytes counts diminished.3）Expression of centromere protein CenpB in leukocytes is distinctly correlated to bone marrow suppression and FPP intervention（P〈0.05）,providing an interesting detection index.