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430例围绝经期失眠症患者肾虚肝郁证的判别分析
  • ISSN号:1673-1727
  • 期刊名称:中华中医药杂志
  • 时间:2014.1.1
  • 页码:181-183
  • 分类:R971[医药卫生—药品;医药卫生—药学]
  • 作者机构:[1]福建省中医药研究院,福州350003, [2]福建省第二人民医院,福州350003, [3]福建中医药大学中西医结合学院,福州350108
  • 相关基金:国家自然科学基金(No.81173149),福建省科技厅专项基金资助课题(No.2012fjzyyk-3).福建省卫生厅青年科研课题(No.2012-1-33)
  • 相关项目:基于中医阴阳寤寐学说的失眠/多睡与睡眠物质及GABAB受体的相关性研究
中文摘要:

目的:采用判别分析法探讨围绝经期失眠症患者肾虚肝郁证的诊断规律。方法:收集430例围绝经期失眠症患者,制定肾虚肝郁证的中医证候调查问卷,包括常见的36种症状和体征,将患者中医辨证分为肾虚肝郁证284例和非肾虚肝郁证146例,并将临床症状分为“有”和“无”2级,分别计为“1”和“0”分。根据患者中医证型对变量进行逐步判别分析,将有显著贡献的变量建立判别函数式,并使用逐一回代法和刀切法对函数式的一致率进行检验。结果:筛选出对区分肾虚肝郁证有显著贡献的10个变量:潮热、情绪抑郁、善太息、五心烦热、急躁易怒、盗汗、苔少(或苔薄或薄黄)、腰膝酸软、舌红和目睛干涩。建立围绝经期失眠症肾虚肝郁证的中医证型判别函数为:肾虚肝郁证=-6.310+1.367×舌红+2.763×苔少(或苔薄或薄黄)+3.897×情绪抑郁+3.102×急躁易怒+3.706×潮热+1.682×盗汗+2.715×五心烦热+3.897×善太息+1.066×目睛干涩+1.588×腰膝酸软;非肾虚肝郁证=-1.858+0.414×舌红+1.653×苔少(或苔薄或薄黄)+0.315×情绪抑郁+1.840×急躁易怒+0.594×潮热-0.068×盗汗+0.286×五心烦热+0.484×善太息+0.065×目睛干涩+0.463×腰膝酸软。逐一回代法判别总一致率为91.2%,刀切法计算一致率为90.7%。结论:围绝经期失眠症。肾虚肝郁证判别函数与临床诊断吻合良好,可提高围绝经期失眠症中医诊断的客观性和准确性。

英文摘要:

Objective: To explore the diagnosis rules of kidney-deficiency and liver-stagnation syndrome of menopausal insomnia patients with discriminatory analysis. Methods: The data of 430 menopausal insomnia patients was collected, A questionnaire on kidney-deficiency and liver-stagnation syndrome of insomnia was worked out, which included 36 common symptoms of menopausal insomnia. The patients were differentiated into two syndromes: kidney-deficiency and liver -stagnation (284 cases) and non-kidney deficiency and liver stagnation (146 cases). The clinical symptoms were marked as 'yes' and 'no', and scored as '1' and '0'. According to the TCM symptom of patients, the variabilities were step-by-step discriminatively analyzed, those significant contributors were attributed into the discriminant function formulae, and the uniformity of which were tested with returning-replacement and knife-cut methods. Results: The 10 variabilities of significant contribution in differentiating the two syndromes were screened out as following: hectic fever, depression, sighs, hot sensation in chest, palms and soles, bad temper, night sweat, less coating of tongue, soreness and weakness of lower back and knee, red tongue, and eye acerbity. The discriminant function formulae were established as: kidney deficiency and liver stagnation=-6.310+1.367×red tongue+2.763×less coating of tongue+3.897×depression+3.102×bad temper+3.706×hectic fever+1.682×night sweat+2.715×hot sensation in chest, palms and soles+3.897×sighs+1.066×eye acerbity+1.588×soreness and weakness of lower back and knee; non-kidney deficiency and liver stagnation=-1858+0.414×red tongue1.653×less coating of tongue+0.315×depression+1.840×bad temper+0.594×hectic fever- 0.068×night sweat+0.286×hot sensation in chest, palms and soles+0.484×sighs+0.065×eye acerbity+0.463×soreness and weakness of lower back and knee. The total uniformity examined by the returning-replacement step-by-step was 91.2%,

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期刊信息
  • 《中华中医药杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国中医药学会
  • 主编:佘倩
  • 地址:北京市和平街北口樱花路甲4号
  • 邮编:100029
  • 邮箱:
  • 电话:
  • 国际标准刊号:ISSN:1673-1727
  • 国内统一刊号:ISSN:11-5334/R
  • 邮发代号:18-90
  • 获奖情况:
  • 国家中医药管理局优秀期刊一等奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,美国剑桥科学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:36061