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中文摘要：
iASPP（inhibitor of ASPP family）是p53凋亡刺激蛋白家族ASPP（apoptosis stimulating protein of p53）中唯一的一个抑制因子,能够抑制p53诱导的细胞凋亡。iASPP基因在癌组织中表达上调,对肿瘤发生、发展起重要促进作用,具有早期诊断价值。进一步的研究显示iASPP基因沉默后,肿瘤细胞凋亡增强,使其有望发展成为肿瘤治疗的新靶点。
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