中文摘要：

自身免疫性肝病是一组由异常自身免疫介导的肝胆炎症性损伤，主要包括自身免疫性肝炎、原发性胆汁性胆管炎及原发性硬化性胆管炎等。作为非病毒性肝病的重要成员，自身免疫性肝病的诊断与治疗日益成为肝病领域的突出问题之一。2016年，自身免疫性肝病在临床和基础研究方面又有了许多新进展，包括奥贝胆酸的临床III期试验，UK—PBC危险评分的提出，以及原发性硬化性胆管炎相关的肠道微生态研究等。现就自身免疫性肝病2016年的诊疗与研究进展进行介绍。

英文摘要：

Autoimmune liver diseases are a group of abnormal autoimmune-mediated inflammatory hepatobiliary injuries, mainly including autoimmune hepatitis（AIH）, primary biliary cholartgitis（PBC）, and primary sclerosing cholangitis （PSC）. The diagnosis and treatment of autoimmune liver diseases, an important type of non- viral liver disease, have become a prominent issue in hepatology. In 2016, many new advances have been achieved in the clinical and basic research on autoimmune liver diseases, including the phase 3 clinical trial of obeficholic acid, the proposal of UK-PBC risk score, and the research on gut microbiota associated with PSC. This article reviews the research advances in the diagnosis and treatment of autoimmtme liver diseases in 2016.