中文摘要：

目的观察丹参多酚酸盐对百草枯诱导的大鼠急性肺损伤的治疗作用。方法成年雄性Wister大鼠120只，随机分为3组，每组40只。百草枯染毒组：一次性灌胃按50 mg/kg给予20%百草枯原液；丹参多酚酸盐治疗组：一次性灌胃50 mg/kg给予20%百草枯原液，然后每日给予丹参多酚酸盐200 mg/kg大鼠体重腹腔注射；空白对照组给予等量生理盐水灌胃。染毒组、治疗组和空白对照组分别于不同处理的第3、7、14、21天麻醉取材，留取静脉血、肺组织待检。静脉血检测血红素氧合酶-1（HO-1），肺组织检测血红素氧合酶-1（HO-1）、羟脯氨酸（HYP）。部分肺组织HE和Masson染色，进行病理组织学检查。结果与对照组比较，染毒组第7、14、21天血清及肺组织HO-1水平升高，治疗组第3、7、14、21天也升高，且第3、7、14天高于染毒组，差异均有统计学意义（P〈0.05）。与对照组比较，治疗组第3天和染毒组第14、21天肺组织HYP含量明显升高，差异均有统计学意义（P〈0.05）；与染毒组相比，第21天治疗组HYP含量明显减低，差异有统计学意义（P〈0.05）。光学显微镜观察，染毒组肺组织损伤随着染毒天数增加而加重，炎性细胞浸润，肺泡间隔纤维化逐渐形成。治疗组实验动物肺组织炎症减轻，肺纤维化程度减轻。结论急性肺损伤大鼠血清HO-1表达及肺组织中HO-1、HYP含量明显增高，丹参多酚酸盐影响HO-1、HYP的表达，从而使急性肺损伤和肺纤维化减轻。

英文摘要：

ObjectiveTo establish to paraquat poisoning acute lung injury animal model to study the therapeutic effect of Salvia polyphenols acid salt of paraquat-induced acute lung injury.MethodsAdult male Wister rats 120, were randomly divided into three groups： the paraquat exposure group, the start of the experiment to give a one-time 20% paraquat dope orally 50 mg/kg body weight of rats; salvianolate treatment group, the start of the experiment paraquat to give a one-time 20% the stock solution orally 50 mg/kg body weight of rats, and then given daily intraperitoneal injection of 200 mg/kg body weight of rats salvianolate; blank control group was given the same amount normal saline. The exposure group, the treatment group and control group rats were sacrificed after anesthesia in the 3rd, 7th, 14th, 21st day from the beginning of the experiment respectively, and taken out and preserved venous blood specimens and lung tissue to be tested. Venous detection heme oxygenase-1 （HO-1） , the lung tissue detection heme oxygenase-1 （HO-1） , hydroxyproline （HYP） . And do biopsy specimens from some of the lung tissue, HE and Masson staining observed by optical microscope.ResultsCompared with control group, model group 7, 14, 21 days had elevated levels of serum and lung tissue HO-1 （all P〈0.05） ; Treatment group 3, 7, 14, 21 days increased （all P〈0.05） , and 3, 7, 14 days is higher than the model group （compared with model group, P〈0.05） . Compared with control group, treatment group 3 days and model group, 14, 21 days HYP content in lung tissue increased significantly （all P〈0.05） ; 21 days, compared with model group, HYP content of treatment group reduce obviously, the difference was statistically significant （P〈0.05） . Optical microscope observation, lung tissue damage and aggravated with the experimental increase in the number of days, inflammatory cell infiltration, alveolar septal fibrosis gradually formed. The treatment group experimental animal lung tissue to reduce inflammation,