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补气中药治疗癌性疲劳随机对照临床研究文献Meta分析
  • ISSN号:1009-0754
  • 期刊名称:《海军医学杂志》
  • 时间:0
  • 分类:R195.1[医药卫生—卫生统计学;医药卫生—卫生事业管理;医药卫生—公共卫生与预防医学]
  • 作者机构:[1]四川大学华西医院,成都610041
  • 相关基金:国家自然科学基金(81202784)
中文摘要:

目的运用Meta分析的方法,评价中医药补气药治疗癌性疲劳的临床疗效。为癌性疲劳的中医药治疗提供科学依据。方法以"癌性疲劳"相关词汇,"中药"、"中医药"、"草本植物"、"替代治疗"、"姑息治疗"等为关键词,在Pub Med、Cochrane图书馆、中国知网、维普中文科技期刊数据库、万方数据库、中国生物医学文摘进行1994-2014年间相关的随机对照试验(RCT)文献搜索。文献资料按Cochrane推荐的Cochrane风险偏倚评估工具进行评估。并运用Rev Man5.3统计软件进行Meta分析。结果共纳入文献19篇。英文文献4篇,中文文献15篇,共1 904例患者。Meta分析结果显示:试验组和对照组在治疗有效率[RR=1.72,95%CI(1.55,1.92)]、BFI量表评分[RR=1.92,95%CI(1.61,2.29)]、中医症状评分[RR=1.59,95%CI(1.27,1.99)]方面的差异具有统计学意义(P〈0.05)。结论现有证据表明,中药补气药在改善癌性疲劳患者疲乏状态及生活质量、中医症状方面具有统计学意义。但尚需大规模、多中心、随机对照试验进一步验证。

英文摘要:

Objective According meta-anlysis to asses tonic medicine in the treatment of cancer related fatigue(CRF).To provide the scientific basis for Chinese medicine treatment of CRF.Methods “cancer related fatigue”,“Chinese herb”,“traditional Chinese medicine”,“botanicals”,“complementary medicine”,“palliative medicine”as keywords,We searched PubMed,the Co-chrane library,Cnki,Vip,Wanfang med online,Chinese biomedical literature on disc(CBM)of relevant randomized controlled trail (RCT)literature in 1994 -2014.The quality of RCT was assessed according to “the cochrane collaboration′s tool for assessing risk of bias”,which recommended by the cochrane library.Meta-anlysis were conducted with the cochrane collaboration′s RevMan 5.3.Results A total of nineteen literatures,involving 1904 patients with CRF.The results of meta-analysis showed that the experimental group and the control group have significant differences in the effective rate[RR =1.72,95%CI(1.55,1.92)],Brief fatigue inventory[RR =1.92,95%CI(1.61,2.29)],Traditional-Chinese-medicine-symtom-score system[RR =1.59,95%CI(1.27,1.99)](P 〈0.05). Conclusion The evidence currently available indicates that Tonic medicine had a statistically significant Improve traditional Chinese medicine symtom and the quality of life of patients with CRF.But further large scale,high quality RCTs are needed.

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期刊信息
  • 《海军医学杂志》
  • 中国科技核心期刊
  • 主管单位:海军后勤部
  • 主办单位:海军后勤部卫生部 海军医学研究所
  • 主编:管柏林
  • 地址:上海市翔殷路880号
  • 邮编:200433
  • 邮箱:bjyx@chinajournal.net.cn
  • 电话:021-81883316
  • 国际标准刊号:ISSN:1009-0754
  • 国内统一刊号:ISSN:31-1823/R
  • 邮发代号:4-858
  • 获奖情况:
  • 曾获全军优秀期刊奖和优秀编辑奖
  • 国内外数据库收录:
  • 中国中国科技核心期刊
  • 被引量:6319