中文摘要：

基因模型是极大地在研究的基因流行病的研究和许多的分析重要在添加剂模型下面用趋势测试被进行。为许多复杂疾病和特点，然而，为一个基因地点的内在的基因模型通常是不明确的。没有基因模型的柔韧的测试因此是适当的。在这份报纸，作者由合并 Hardy-Weinberg 平衡信息建议嵌入模型的趋势测试并且获得明确的公式计算它的统计意义。广泛的模拟研究证明建议测试比存在过程更柔韧。最后，真实应用进一步被分析显示出建议测试的表演。

英文摘要：

The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test.