中文摘要：

目的 探讨规范补充维生素D （VitD）对高血压患者血压控制的影响,为临床治疗高血压提供支持.方法 收集高血压患者100例,按自愿原则分为两组,每组50例,其中一组为单纯规范治疗组,设为对照组,另一组为研究组,在规范治疗的同时每天添加VitD 25 μg.应用酶联免疫吸附试验（ELISA）测定两组25羟基VitD[25 （OH）D]含量,跟踪时间持续一年,其间监测两组血压控制情况,计算两组收缩压及舒张压均值及其变异系数,将两组结果进行对比分析.结果 治疗后,研究组25（OH）D含量为（110.3±24.5） μg/L;收缩压（144±16） mmHg,变异系数（CV）为11.1％;舒张压（87±9）mmHg,CV为10.3％.对照组25（OH）D含量为（30.1±14.9）μg/L;收缩压（145±27） mmHg,CV为18.6％;舒张压（89±10） mmH g,CV为12.4％.研究组与对照组比较,25（OH）D含量、收缩压CV差异有统计学意义（t=12.47,Х^2=6.72,均P＜0.01）,舒张压CV差异无统计学意义（Х^2 =0.97,P＞0.05）.结论 规范治疗高血压的同时定量补充VitD,有利于高血压患者收缩压水平控制,但对舒张压影响无实际意义.

英文摘要：

Objective To investigate the effect of controlling blood pressure in treating patients with hypertension by taking quantitative vitamin D to provide support for the clinical treatment of patients with hypertension.Methods 100 cases with hypertension were randomly divided into the two groups voluntarily,50 cases in each group and one group with a simple standard treatment was considered as the control group,and the other one was the study group,25μg/d vitamin D was taken besides standard treatment.Each group content of 25-hydroxyvitamin D [25 （OH）D] level were measured by Enzyme-linked immunosorbent assay （ELISA） and lasted for one year to detect the situation of controlling blood.Mean and variable coefficient of systolic and diastolic blood pressure were calculated and compared each other.Results After treatment,the content level of 25 （OH）D was （110.3 ± 24.5）nmol/L,systolic pressure was （144 ± 16） mmHg,variable coefficient was 11.1%,diastolic pressure was （87 ± 9） mmHg,variable coefficient was 10.3% in experiment group;while the content of level of 25 （OH）D was （30.1 ± 14.9）mol/L,systolic pressure was （145 ± 26）mmHg,variable coefficient was 17.9%,diastolic pressure was （87 ± 10）mmHg,variable coefficient was 12.4% ;the content of level of 25 （OH）D,variable coefficient of systolic pressure had statistical difference （t =12.47,Х^2 =6.72,P 〈 0.01）,variable coefficient of diastolic pressure had no statistical difference （P 〉 0.05）.Conclusion Taking quantitative vitamin D besides standard treatment is benefit for controlling the level of systolic pressure in patients with hypertension but is meaningless to the level of diastolic pressure.