中文摘要：

通过单因素试验分析了乙醇体积分数、液料比、提取温度和提取时间对橙皮苷得率的影响，在此基础上选择4因素3水平的Box—Behnken中心组合试验设计，采用响应面法对橘皮中橙皮苷的提取工艺进行了优化。结果表明：最佳提取工艺条件为溶剂中乙醇体积分数71％，液料比22：1mL／g，提取温度70℃，提取时间2．5h。经试验验证，在此条件下，得率达4．82％。对橙皮苷提取液的抗氧化研究表明，橙皮苷对羟自由基有一定的清除作用。

英文摘要：

Four factors including ethanol concentration, solvent to material ratio, extraction temperature and ex-traction time were studies on the yield of hesperidin from the citrus peel by using single factor analysis method. Then a four factor, three-level Box-Behnken central composite design （CCD） coupled with response surface analysis （RSM） was applied in optimization of the extraction. It was found that the optimum extraction conditions were ： etha-nol concentration 71% , solvent to material ratio 22：1 （mL/g） , extraction temperature 70℃ and extraction time 2.5 h. Under the optimized extraction conditions, hesperidin extraction yield was 4.82%. The research on anti-oxidation properties showed that the extracted hesperidin had scavenging activity on free hydroxyl radical.