中文摘要：

采用半互穿网络技术,将具有生物相容性的丝胶蛋白（silk sericin）作为第二网络进入聚（N-异丙基丙烯酰胺）（PNIPAM）水凝胶网络中,在水溶液中制备得到具有半互穿网络结构的丝胶基温敏水凝胶（SS/PNIPAM semi-IPNs）.采用称重法研究了产物的（消）溶胀、温度敏感性、最大溶胀度及脉冲响应行为;利用扫描电镜（SEM）,差示扫描量热仪（DSC）和动态热机械分析仪（DMA）分别考察了产物的内部形态、热相转变行为和其储能模量随温度的变化.结果表明：具有较高亲水性的丝胶蛋白的引入增大了semi-IPNs水凝胶的内部孔径,导致SS/PNIPAM半互穿水凝胶的溶胀度增加,并且其储能模量随温度变化更明显.相比于纯PNIPAM水凝胶,半互穿水凝胶的消溶胀速率和低临界溶解温度（LCST）变化不大.

英文摘要：

A novel temperature-sensitive semi-interpenetrating （semi-IPNs） hydrogels based on biocompatible silk sericin （SS） and poly（N-isopropylacrylamide） （PNIPAM） were prepared by semi-IPNs method in aqueous solution. The （de）swelling behaviors, temperature-sensitivity, maximum swelling degree and impulse response behaviors of the hydrogels were studied by weighing method. The interior morphology, phase transition behaviors and dependence of storage modulus on temperature of the hydrogels were inves- tigated by means of scanning electron microscope （SEM）, differential scanning calorimetry （DSC） and dy- namic mechanical analysis （DMA）, respectively. The results showed that the incorporation of high hydro-philic SS increases the pore size of the semi-IPNs hydrogels, resulting in higher swelling degree and apparent decrease of storage modulus upon temperature. In comparison with traditional PNIPAM hydrogel, the deswelling ratios and lower critical solution temperature （LCST） of the semi-IPNs hydrogels haven’t obvious difference.