中文摘要：

瞄准：在一张中国人口调查在 TBX21 基因的多型性和胃的癌症的风险之间的协会。方法：位于 TBX21 基因倡导者区域的 -1993 多型性被聚合酶链反应限制识别碎片长度多型性(PCR-RFLP ) 方法。在 TBX21 基因遗传型和胃的癌症之间的风险被在 220 个胃的癌症病人和 262 没有癌症的控制的逻辑回归分析到年龄，性别和种族匹配的 multivariate 决定。结果：与 TBX21 -1993TT 遗传型相比， -1993CC 遗传型为胃的癌症展出了显著地提高的风险[机会比率(或)= 3.42， 95% 信心间隔(CI ) ：1.41-8.31 ] 。在象淋巴节点和远转移那样的多态的遗传型和侵略地位在胃的癌症病人之中被发现的 -1993 之间的关系(或 = 4.02， 95% CI：1.87-8.66；或 = 7.02， 95% CI：3.44-14.34，分别地) 。结论：TBX21 -1993 多型性可能贡献胃的癌症的风险，特别到远转移。

英文摘要：

AIM： To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population. METHODS： The -1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reactionrestriction fragment length polymorphism （PCR-RFLP） method. The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age, sex and ethnicity. RESULTS： Compared with the TBX21 -1993TT genotype, the -1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio （OR） = 3.42, 95% confidence interval （CI）： 1.41-8.31]. The relation-ship between the -1993 polymorphic genotype and the invasive status such as lymph node and distant metastasis was found among the gastric cancer patients （OR = 4.02, 95% CI： 1.87-8.66; OR = 7.02, 95% CI： 3.44-14.34, respectively）. CONCLUSION： TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.