中文摘要：

背景 Radiofrequency 导管脱离( RFCA )必然生产心肌的 necrosis.However 的一个区域，在环绕的肺的静脉隔离( CPVI )和建筑群之间的心肌的损害的程度的差别在有 atrial 纤维性颤动( AF )的病人的 fractionated atrial 电记录图( CFAE )脱离一直不是调查 before.Methods 有发作性或坚持的 AF 的 29 个连续男病人( n=29 )为 CPVI 被选择或 CFAE ablation.The CPVI 或 CFAE 脱离

英文摘要：

Background Radiofrequency catheter ablation （RFCA） necessarily produces an area of myocardial necrosis. However, the difference of the extent of myocardial injury between circumferential pulmonary vein isolation （CPVI） and complex fractionated atrial electrograms （CFAE） ablation in patients with atrial fibrillation （AF） has not been investigated before. Methods Twenty-nine consecutive male patients （n=29） with either paroxysmal or persistent AF were selected for CPVI or CFAE ablation. The CPVI or CFAE ablation was performed with a three-dimensional electroanatomical mapping system （CARTO）. Serum cardiac biomarkers, for example, cardiac troponin T （cTnT）, aspartate transaminase （AST）, lactate dehydrogenase （LDH）, creatine kinase （CK）, and creatine kinase myocardial bound （CKMB） were determined by the Elecsys STATE immunoassay. Cardiac structure and function were measured with echocardiography. Results Echocardiography showed that there was no significant difference of atrioventricular structure or function parameters between the CPVI group and the CFAE ablation group. Serum cTnT showed a significant increase in the CFAE ablation group over the CPVI group at 12 and 24 hours after the procedure （P〈0.05, respectively）, and then it was reduced to a normal level after 48 hours. Serum AST showed a significant increase in the CFAE ablation group over the CPVI group at post-procedure, 4 and 12 hours after the procedure （P 〈0.05, respectively）, and then it reached to a normal level after 24 hours. There was no significant difference in LDH, CK, or CKMB levels between the CFAE ablation group and the CPVI group at any time point （P〉0.05）. Conclusions cTnT and AST other than LDH, total CK or CKMB activity significantly increased more in the CFAE ablation group than the CPVI group. However, the difference of the serum levels of cTnT, AST between two groups was temporary.