中文摘要：

综述了国外在糖尿病重要并发症糖尿病肾病的肾纤维化病变发病机制方面的最新进展，指出多元醇糖代谢支路与醛糖还原酶的异常激活、转化生长因子-β（TGF-β）／Smad信号转导途径的异常激活可能是糖尿病肾病肾脏炎症和肾纤维化病变的主要机制，此外，miR—NAs也可能通过影响TGF—β信号转导途径达到影响糖尿病肾病肾纤维化病变进程的作用。

英文摘要：

It reviewed the foreign latest progress on the pathogenesis of renal fibrosis lesions in diabetic nephropathy of important diabetic complications. And it pointed out that abnormal polyhydric alcohol sugar metabolism branch and abnormal activation of aldose reductase, abnormal activation of TGF - β/Smad signal transduction pathways may be main mechanisms of kidney inflammation in diabetic nephropathy and renal fibrosis lesions. In addition, miRNAs may also influence the renal fibrosis process in diabetic nephropathy through impacting the TGF -β signal transduction pathways.