中文摘要：

目的：明确儿茶酚衍生物苯环上羟基及甲氧基取代对小鼠焦虑行为的影响。方法：采用小鼠高架十字迷宫模型,评价含有酚羟基的3,4-二羟基苯乙酮、香草乙酮、阿魏酸和不含酚羟基的3,4-二甲氧基肉桂酸、甲基丁香酚、甲基香草醛等儿茶酚衍生物对小鼠焦虑行为的影响。结果：含有2个酚羟基的3,4-二羟基苯乙酮（20mg/kg）具有明显的抗焦虑活性（P〈0.01）;含有1个酚羟基的阿魏酸（5、10、20mg/kg）具有明显的抗焦虑作用（P〈0.05,P〈0.01）,而香草乙酮有增加评价指标的趋势但无显著抗焦虑作用;不含酚羟基的3,4-二甲氧基肉桂酸无抗焦虑和致焦虑活性,甲基丁香酚（5mg/kg）及甲基香草醛（1.25mg/kg）具有明显的致焦虑活性（P〈0.05,P〈0.01）。结论：儿茶酚苯环上羟基、甲氧基取代衍生物可分别产生抗焦虑、致焦虑两种相反的作用,儿茶酚衍生物影响小鼠焦虑行为的构效关系值得深入研究。

英文摘要：

Objective： To clarity the effects of catechol derivatives with hydroxyl or methoxy groups in substituted on anxiety behaviors in mice. Methods： The effects of catechol derivatives contained 3,4-dihydroxyacetophenone, acetovanillone, ferulic acid and did not contain 3,4-dihydroxyacetophenone, methyleugenol, methylvanillin on the anxiety behavior of mice were evaluated by elevated plus maze. Results： In the elevated plus maze, 3,4-dihydroxyacetophenone（20mg/kg） with two phenolic hydroxyl showed significant anxiolytic effects（P〈0.01）. Ferulic acid（5, 10, 20 mg/kg） with one phenolic hydroxyl had significant anxiolytic effects（P〈0.05, P〈0.01）, while acetovanillone showed an increasing trend in the evaluation index but without significant anxiolytic effect. 3,4-dimethoxycinnamic acid without phenolic hydroxyl did not have anxiolytic or anxiogenic activity. However, methyleugenol（5mg/kg）, methylvanillin（1.25mg/kg） showed obviously anxiogenic activities（P〈0.05, P〈0.01）. Conclusion： Catechol derivatives with hydroxyl or methoxy groups in substituted had anxiolytic or anxiogenic effects on the anxiety behaviors in mice, the specific structure-activity relationship was worthy of further investigation.