位置：成果数据库 > 期刊 > 期刊详情页
Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma
  • ISSN号：1000-467X
  • 期刊名称：《癌症：英文版》
  • 分类：Q754[生物学—分子生物学] Q75[生物学—分子生物学]
  • 作者机构：[1]Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P. R. China, [2]Department of Pathology, Cancer Hospital & Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, P. R. China, [3]Cancer Epigenetics Laboratory, Department of Clinical Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong and CUHK Shenzhen Research Institute, Shenzhen, Guangdong 518055, P. R. China, [4]Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)-CUHK. Shenzhen. Guangdong 518055, P. R. China., Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)-CUHK. Shenzhen. Guangdong 518055, P. R. China., Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)-CUHK. Shenzhen. Guangdong 518055, P. R. China., Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)-CUHK. Shenzhen. Guangdong 518055, P. R. China
  • 相关基金：supported by NSFC Joint Research Fund for Hong Kong and Macao Young Scholars(No.30928012);National Natural Science Foundation of China(No.81071634,81172582,and 30801344);Shenzhen Science Fund for Distinguished Young Scholars(No.JC201005270328A)
作者： Ji-Sheng Li[1], Jian-Ming Ying[2], Xiu-Wen Wang[1], Zhao-Hui Wang[3,4], Qian Tao[3,4], LI-Li Li[3,4]
关键词： 基因启动子, 抑癌基因, 鳞状细胞癌, 食管癌, 甲基化, 肿瘤抑制基因, 肿瘤标志物, 表观遗传, Tumor suppressor gene, CpG island, promoter methylation, esophageal squamous cell carcinoma, tumor marker
中文摘要：

Esophageal squamous cell carcinoma(ESCC) is a prevalent and fatal cancer in China and other Asian countries.Epigenetic silencing of key tumor suppressor genes(TSGs) is critical to ESCC initiation and progression.Recently,many novel TSGs silenced by promoter methylation have been identified in ESCC,and these genes further serve as potential tumor markers for high-risk group stratification,early detection,and prognosis prediction.This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC,providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.

英文摘要：

Esophageal squamous cell carcinoma （ESCC） is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes （TSGs） is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.

同期刊论文项目
甲基化的新抑癌基因RNF180的功能、分子机制及肿瘤标志物的研究
期刊论文 11
肾细胞癌新抑癌基因的鉴定及其表观遗传学改变作为早期肿瘤分子标志物的应用
期刊论文 6
食管鳞癌早期诊断及预后相关表观遗传学标记物的筛选及应用
期刊论文 4
表观遗传异常所致新的抑癌基因CDH11调节Wnt信号通路参与细胞癌变及作为头颈肿瘤分子标志物的研究
期刊论文 22
同项目期刊论文
Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin a
Epigenetic silencing of WNT5A in Epstein-Barr virus-associated gastric carcinoma
FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is freque
Lipid-polymer nanoparticles encapsulating doxorubicin and 2'-deoxy-5-azacytidine enhance the sen
Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling
Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma.
Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1 in tumor
A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome
Aberrant promoter CpG methylation and its translational applications in breast cancer
Epigenetic disruption of cell signaling in nasopharyngeal carcinoma
The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/&
Chromatin regulators with tumor suppressor properties and their alterations in human cancers.
Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and a
Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis
Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignantepithelial ce
SOX10, a novel HMG-box-containing tumor suppressor, inhibits growth and metastasis of digestive canc
OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT v
Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cells
The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-cat
WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in
Genome-wide genomic alterations in esophageal cancer identified by 1-Mb aCGH pinpoint CCND1 at 11q13
Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, i
The Epigenetic Modifier PRDM5 Functions as a Tumor Suppressor through Modulating WNT/ β-Catenin Sign
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in car
Aberrant promoter CpG methylation and its translational applications in breast cancer
期刊信息
  • 《癌症：英文版》
  • 北大核心期刊（2008版）
  • 主管单位:教育部
  • 主办单位:中山大学肿瘤防治中心
  • 主编：曾益新
  • 地址：中国广州市东风东路651号
  • 邮编：510060
  • 邮箱：cjc@cjcsysu.cn
  • 电话：020-87345651
  • 国际标准刊号：ISSN：1000-467X
  • 国内统一刊号：ISSN：44-1195/R
  • 邮发代号:46-21
  • 获奖情况:
  • 广东省优秀期刊鼓励奖，1991年,2009、2010、2011年百杰期刊,2011-2014年RCCSE中国权威期刊,2012年中国国际影响力优秀学术期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,瑞典开放获取期刊指南,中国北大核心期刊（2000版）
  • 被引量:30766