中文摘要：

信使RNA的核苷酸修饰主要包括2＇-O-甲基化、假尿嘧啶化、m6A、m5C、m7G、m1A、5hm C等。已有的研究表明,这些修饰在m RNA稳定性、加工、遗传信息传递以及细胞的应激反应中起到重要作用。由于技术的限制,过去我们对于m RNA修饰知之甚少。近年来,一系列新技术的产生为全面地考察m RNA核苷酸修饰状况,深入地研究它们的生物学功能提供了极大的便利,并且取得了一些重要的进展。就此方面的研究概况作简要概述。

英文摘要：

Nucleotide modifications of messenger RNA include 2＇-O-methylation, pseudouridylation, m6 A, m5 C, m7 G, m1 A, 5hm C, etc. Previous studies have shown that these modifications play an important role in m RNA stability, processing, transmission of genetic information and cellular stress response. As a result of the limitation of technology, we know very little for m RNA modification in the past. Recently, a series of new technology provide great convenience for comprehensive inspection and further biological function research of m RNA nucleotide modification and have already made some important progress. This review introduced the research progress and prospects of m RNA modification.