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The study on the mechanical characteristics of articular cartilage in simulated microgravity

ISSN号：0567-7718
期刊名称：Acta Mechanica Sinica
时间：2012
页码：1488-1493
分类：Q693[生物学—生物物理学] Q954.657[生物学—动物学]
作者机构：[1]Key Laboratory of the Ministry of Educationfor Biomechanics and Mechanobiology,State Key Laboratory of Software Development Environment,School of Biological Science and Medical Engineering,Beihang University, 100191 Beijing, China, [2]School of Biomedical Engineering,Southern Medical University,510515 Guangzhou, China, [3]Department of Ultrasound,People Liberation Army General Hospital,100853 Beijing, China
相关基金：The project was supported by the National Natural Science Foundation of China （31170896） and State Key Laboratory of Software Development Environment （SKLSDE-2011ZX- 11）.
相关项目：生物力学及生物力学工程

关键词：模拟微重力, 关节软骨, 机械特性, 载人航天飞行, 骨骼系统, 固体基质, 弹性模量, 微重力环境, Simulated microgravity , Articular cartilage.Triphasic theory , High-frequency ultrasound , Uniaxialmodulus

中文摘要：

一架长期的空间班机的 microgravity 环境可以导致尖锐变化在一宇航员肌与骨的系统。这研究在关节的软骨的机械特征上探索模仿的 microgravity 的效果。六只老鼠经历了尾巴暂停因为 14 天和六只另外的老鼠作为控制在正常地球严肃下面被保留。胀大的紧张在所有软骨样品题目用高周波的超声被测量到渗透的装载。地点特定的胀大紧张数据在 triphasic 被使用软骨胀大决定软骨固体矩阵的单轴的模量的理论模型。没有严重表面不规则在从控制或推迟尾巴的组获得的软骨样品被发现。为推迟尾巴的组，在一个指定地点的软骨的厚度由超声回响决定了显示出次要的减少。在指定地点的关节的软骨的单轴的模量显著地减少了，从(6.31

英文摘要：

The microgravity environment of a long-term space flight may induce acute changes in an astronaut＇s musculo-skeletal systems. This study explores the effects of simulated microgravity on the mechanical characteristics of articular cartilage. Six rats underwent tail suspension for 14 days and six additional rats were kept under normal earth gravity as controls. Swelling strains were measured using high-frequency ultrasound in all cartilage samples subject to osmotic loading. Site-specific swelling strain data were used in a triphasic theoretical model of cartilage swelling to determine the uniaxial modulus of the cartilage solid matrix. No severe surface irregularities were found in the cartilage samples obtained from the control or tail-suspended groups. For the tail-suspended group, the thickness of the cartilage at a specified site, as determined by ultrasound echo, showed a minor decrease. The uniaxial modulus of articular cartilage at the specified site decreased significantly, from （6.31 ± 3.37） MPa to （5.05 ± 2.98）MPa （p 〈 0.05）. The histology- stained image of a cartilage sample also showed a reduced number of chondrocytes and decreased degree of matrix staining. These results demonstrated that the 14 d simulated microgravity induced significant effects on the mechanical characteristics of articular cartilage. This study is the first attempt to explore the effects of simulated microgravity on the mechanical characteristics of articular cartilage using an osmotic loading method and a triphasic model. The conclusions may provide reference information for manned space flights and a better understanding of the effects of microgravity on the skeletal system.