目的:研究人参皂苷M1酯化产物的结构。方法:用月桂酸、二亚胺与M1进行酯化反应,采用柱硅胶层析法分离纯化,利用IR,UPLC/QTOFMS和NMR(1D和2DNMR)等现代波谱技术手段鉴定了它们的结构。结果:分离得到了三种化合物,其中它们的结构分别为M1结构中葡萄糖单元3-OH,4-OH,6-OH位引入酯基。结论:在M1中葡萄糖单元上发生酰化反应,合成出三种新的M1衍生物。
AIM: To study the structures of esterification products derived from ginsenoside MI and dodecanoic acid. METHOD: The esterified compounds were prepared from the reaction of ginsenoside M1 dodecanoic acid and diimide, and pure prodcuts were obtained by Silica gel column chromatography. Their structures were characterized by IR, UPLC/Q TOF MS and NMR (1D and 2D NMR). RESULTS: Structures of three compounds were elucidated as the esetrified M1 acylated at 3-OH, 4-OH, 6-OH in the glucose moiety in M1, respectively. CONCLUSION: Three new M1 derivatives acylated at the glucose moiety were synthesized.