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中文摘要：
目的研究创伤后应激障碍（PTSD）大鼠杏仁核神经元及突触的超微结构改变。方法采用大鼠PTSD-无连续单一应激（SPS）模型，于SPS刺激后1d、7d、14d取大脑杏仁核组织，制备成超薄切片，进行透射电镜观察。结果模型组杏仁核可见凋亡神经元，尤以SPS-7d为明显，神经元胞质内线粒体外膜局部破损、嵴减少或空泡化，粗面内质网和高尔基复合体呈不同程度扩张，突触结构也有异常。结论PTSD时杏仁核神经元发生凋亡和突触变性改变。
英文摘要：
Objective To observe the uhrastructure change of amygdala neuron and synapse in rats of posttraumatic stress disorder（PTSD）. Method Establishment of single-prolonged stress（SPS） of PTSD rat, materials of amygdala were gained at 1d,7d and 14d after SPS exposure, uhrathin sections were made and the tissues were observed with transmission electron microscope. Results Apoptosis of amygdala neurons was seen in the model, and obviously at 7d after SPS exposure, with rupture of mitochondria external membrane, decreased crests or vacuolization, dilation of rough endoplasmic reticulum and Golgi complex in cytoplasma of neuron, the structure of synapse was also abnormal. Conclusion The uhrastructure of amygdala neuron and synapse was abnormal in PTSD.
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