中文摘要：

目的研究乙酰甲胺磷对幼年大鼠肝脏的脂质过氧化作用。方法80只健康清洁级21d龄Sprague—Dawley雌性大鼠按体重随机分为8组，分别为对照（蒸馏水）组和0．09、0．18、0．37、0．74、1．48、2．95、5．90mg／kg乙酰甲胺磷染毒组，每组10只。连续21d灌胃染毒，每天1次，。测定肝脏中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活力及丙二醛（MDA）含量。结果与对照组比较，0．18～2．95mg／kg乙酰甲胺磷染毒组幼年大鼠肝匀浆中SOD活力均较高，0．37-5．90mg／kg乙酰甲胺磷染毒组幼年大鼠肝匀浆中CAT活力均较高，各剂量乙酰甲胺磷染毒组幼年大鼠肝匀浆中MDA含量均升高，差异有统计学意义（P〈0．05，P〈0．01）。且随着乙酰甲胺磷染毒剂量的升高，幼年大鼠肝匀浆中S01）、CAT活力均呈先上升后下降的趋势，而MDA含量呈上升趋势。结论乙酰甲胺磷可诱导幼年大鼠肝脏的脂质过氧化作用。

英文摘要：

Objective To study the effect of acephate （orthene） on the lipid peroxidation in infant rat liver. Methods A total of 80 female Sprague-Dawley rats aged 21 days were randomly divided into eight groups by weight,including seven dose groups （0.09,0.18,0.37,0.74,1.48,2.95 and 5.90 mg/kg body weight） and one control group （distilled water）, 10 rats in each. The rats were exposed to acephate through garage at the dose of 10 ml/kg body weight once a day for consecutive 21 days. Then the activity of superoxide dismutase （SOD）, catalase （CAT） and the concentration of malondialdehyde（MDA） in the liver were measured. Results Compared with the control group,the activity of SOD in 0.18-2.95 mg/kg groups and the activity of CAT in 0.37-5.90 mg/kg groups were significantly higher （/）〈0.05 ,P〈0.01 ）. In all groups, the concentration of MDA increased and were significantly higher than that of control group （P〈0.01）. As the dose increased,the activity of SOD and CAT first increased and then decreased, while the concentration of MDA always had an upward tendency. Conclusion Acephate can induce the enhancement of lipid peroxidation in infant rat liver. Key words： Aeephate; Infant rats; Superoxide dismutase; Catalase; Malondialdehyde