中文摘要：

缺血缺氧预适应现象最初见于心脏，一经发现即引起了学术界的广泛关注，随后研究者分别从不同层面证实了大脑同样具有预适应现象，并进行了大量的研究，成为抗脑缺血缺氧研究的热点。脑缺血缺氧预适应（cerebral ischemia／hypoxiapreconditioning，CIP）可以通过多种信号传导途径，减少细胞凋亡，提高机体抗氧化能力，减少氧化损伤，升高低氧诱导因子和热休克蛋白HSP70的生成等，各种机制相互联接，相对独立。

英文摘要：

The phenomenona of ischemia/hypoxia preconditioning were first discovered in heart. Numerous studies, carried out at different levels,have confirmed that there are also preconditioning phenomenona in brain,and the phenomenona of ischemia/hypoxia preconditioning in brain have become a hot topic in the field of ischemia and hypoxia. Cerebral ischemia/hypoxia preconditioning （CIP） can decrease cell apoptosis,increase the anti-oxidant ability and decrease oxidant injury, increase the generation of hypoxic inducible factor-1 and heat shock protein 70 through multiple signal transduction pathways. There are interactions among the mechanisms about CIP which are relatively independent.