中文摘要：

目的：探讨乳腺癌患者术前血清纤维蛋白原水平（ plasma fibrinogen concentration，PFC）的临床意义。方法：收集165例接受乳腺癌改良根治性手术、术后病理确诊为乳腺癌、TNM分期、ER/PR及术前PFC资料完整的患者手术标本，免疫组化检测Ki67和p53的表达，分析术前PFC与患者临床病理因素、p53和Ki67之间的关系。结果：乳腺癌患者术前PFC与患者的年龄和淋巴结转移无关，但T2期患者PFC明显高于T1期患者（p=0.048）。PFC与PR及HER-2的表达无关，但是ER阴性患者术前PFC明显高于ER阳性患者（p=0.031）。p53突变型患者的术前PFC明显高于p53野生型患者（ p=0.016）。Ki67阳性患者术前PFC明显高于Ki67阴性患者（ p=0.003）。结论：乳腺癌患者术前PFC是患者体内肿瘤细胞增殖速率的生物标志物。

英文摘要：

Objective：To explore the clinical significance of the preoperative plasma fibrinogen concentration （ PFC）in breast cancer. Methods：Collected the clinical pathological features and preoperative PFC of 165 breast cancer patients. To detect the expression of p53 and Ki67 using immunohistochemical SP method. To explore the rela-tionship between PFC and clinical characters,Ki67 and p53. Results：The preoperative PFC had no significant correla-tion with age and lymph node metastasis. It was correlated with tumor size（p=0. 048）. The T2 stage breast cancer had a higher preoperative PFC than T1 stage. The preoperative PFC had no significant correlation with the expression of PR and HER-2. However,ER positive breast cancer had higher preoperative PFC than ER negative（p=0. 031）. The p53-mutation breast cancer had higher preoperative PFC than p53-wild（p=0. 016）. The Ki67 positive breast cancer had higher preoperative PFC than the Ki67 negative（p=0. 003）. Conclusion：Preoperative PFC was a bio-marker of cell proliferation rate in breast cancer.