目的了解老年2型糖尿病(T2DM)患者尿路感染(UTI)的临床特点,并对相关危险因素进行分析,为临床资料提供参考依据。方法回顾性分析2010年2月-2012年4月1075例老年T2DM患者临床资料,合并UTI患者为病例组(132例),非UTI患者为对照组(943例),比较两组患者临床特征、病原学特点,并对相关危险因素作logistic回归分析。结果1075例老年T2DM患者发生UTI132例,发生率为12.3%,与对照组比较,病例组年龄、糖尿病病程、血糖、糖化血红蛋白、血肌酐及尿路结石比例差异均有统计学意义(P〈0.05);无症状性uTI患者有48例,占36.3%;尿培养共检出病原菌152株,其中革兰阴性菌95株62.5%,革兰阳性菌49株32.2%,真菌8株5.3%;多因素logistic回归分析显示,糖尿病病程(OR=4.209)、血糖水平(OR=2.254)及合并泌尿系结石(OR=1.741)是T2DM患者发生uTI的独立危险因素。结论老年T2DM患者UTI发生率较高,部分患者无典型症状,革兰阴性菌是最常见的病原菌,血糖高、糖尿病病程长和泌尿系结石是T2DM患者发生UTI的独立危险因素。
OBJECTIVE To explore the clinical characteristics of urinary tract infections in elderly patients with type 2 diabetes and analyze the related risk factors so as to provide guidance for clinical data. METHODS From Feb 2010 to Apr 2012, the clinical data of 1075 elderly patients with type 2 diabetes were retrospectively analyzed, then the patients complicated with urinary tract infections were assigned as the case group (132 cases), the patients without urinary tract infections were set as the control group (943 cases), the clinical and etiological char- acteristics were observed and compared between the two groups, and the logistie regression analysis was per- formed to analyze the related risk factors. RESULTS Of the 1075 elderly patients with type 2 diabetes, the urinary tract infections occurred in 132 cases with the incidence rate of 12.3%. The difference in the age, course of diabe- tes, blood glucose, glycated hemoglobin, blood creatinine, or proportion of urinary lithiasis between the ease group and the control was statistieally significant (P〈0.05). There were 48 (36. 3%) cases of asymptomatic urinary tract infections. Totally 152 strains of pathogens have been isolated from urine culture, including 95 (62.5%) strains of gram-negative bacteria, 49 (32.2%) strains of gram-positive bacteria, and 8 (5.3%) strains of fungi. The multivariate logistic regression analysis indicated that the course of diabetes (OR=4. 209), level of blood glucose(OR=2. 254), and complication of urinary lithiasis(OR= 1. 741) were the independent risk factors for the urinary tract infections in the patients with type 2 diabetes. CONCLUSION The incidenee of urinary tract infections is high in the elderly patients with type 2 diabetes, and some of the patients are with asymptomatic symptoms. The gram-negative bacteria are the most common pathogens. The high level of blood glucose, long course of diabetes, and urinary lithiasis are the independent risk factors for the urinary tract infections i