中文摘要：

巨噬细胞经由 secreting 支持 inflammatory 调停人， phagocytosing 微生物和介绍抗原在天生的有免疫力、获得的免疫者起关键作用。Activin A，转变生长因素(TGF-) 总科的一个成员，被巨噬细胞和 microglia 细胞生产。在这研究，我们在老鼠巨噬细胞房间线 RAW264.7 房间上作为一个支持 inflammatory 因素报导了 activin A 的直接效果。我们的数据表明 activin A 不能仅仅从 RAW264.7 房间增加 IL-1 和 IL-6 生产，而且支持 pinocytic 和 RAW264.7 房间的吞噬细胞的活动。另外， activin A RAW264.7 房间的表面上的显然起来调整的 MHC II 表示，而没影响 MHC 我表示。Activin A 也提高了 CD80 表示，它是激活的巨噬细胞的一个标记，但是没影响 RAW264.7 房间增长。这些数据建议 activin A 可以经由支持休息巨噬细胞的激活调整主要调停巨噬细胞的天生、获得的有免疫力的反应。

英文摘要：

Macrophages play critical roles in innate immune and acquired immune v/a secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor （TGF-β） superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC Ⅱ expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages.