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Chiral guanidine catalyzed Michael addition reaction and Diels-Alder reaction of anthrone and N-methylmaleimide
  • ISSN号:1001-604X
  • 期刊名称:《中国化学:英文版》
  • 时间:0
  • 分类:O643.3[理学—物理化学;理学—化学]
  • 作者机构:Department of Chemistry, Fudan University, Shanghai 200433, China, State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
  • 相关基金:Project supported by the Chinese Academy of Sciences and the National Natural Science Foundation of China (grant No. 29725205).
中文摘要:

Two chiral guanidines were evaluated as catalysts for the reaction of anthrone (1) with N-methylmaleimide (2). When guanidine 5 was used, the Michael adduct 4 was isolated as a major product. The best enantioselectivity (70% ee) was obtained when the reaction was carried out in THF at - 20℃.

英文摘要:

Two chiral guanidines were evaluated as catalysts for the reaction of anthrone (1) with N-methylmaleimide (2). When guanidine 5 was used, the Michael adduct 4 was isolated as a major product. The best enantioselectivity (70% ee) was obtained when the reaction was carried out in THF at -20°C.

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期刊信息
  • 《中国化学:英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编:
  • 地址:上海市枫林路354号中科院上海有机化学研究所
  • 邮编:200032
  • 邮箱:
  • 电话:021-54925243
  • 国际标准刊号:ISSN:1001-604X
  • 国内统一刊号:ISSN:31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,美国科学引文索引(扩展库),日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175