中文摘要：

综述了蛋白质巯基亚硝基化修饰的特点、检测方法、功能研究、相关疾病和发展态势．蛋白质巯基亚硝基化（S-nitrosation）是指一氧化氮（nitric oxide，NO）及其衍生物修饰蛋白质半胱氨酸（cysteme，Cys）巯基-SH生成-SNO，其是一种典型的氧化还原依赖的蛋白质翻译后修饰，也是一氧化氮发挥其广泛信号转导作用的新的重要途径．

英文摘要：

S-nitrosation, which involves the formation of an S-nitroso function group on a protein cysteine residue, is a prototypic redox-based post-translational modification of proteins, and thereby conveys a large part of the ubiquitous influence of nitric oxide on cellular signal transduction. A purview of this modification was given mainly concerning the characteristics, the detection methods, the functional effects, the relevant diseases and the perspectives.