中文摘要：

Cedarmycins A和B是近年从放线菌的次生代谢物中分离得到的一种新型的天然抗生素,本文以γ-丁内酯为原料首次合成了该类化合物.其关键步骤为3-溴甲基-5H-呋喃-2-酮与甲醛发生的γ位迁移的Barbier反应.各中间体都通过^1H NMR和^13C NMR得到证实.最终产品通过^1H NMR,^13C NMR和HRMS证实与文献所报道相一致.

英文摘要：

The first synthesis of cedarmycins A and B,which were two novel butyrolactone antibiotics iso-lated from the cultured broth of the actinomycete,was achieved effectively from γ-butyrolactone.The key step was a Barbier reaction of 3-bromomethyl-5H-furan-2-one and formaldehyde to afford the γ-addition product.All structures were confirmed by ^1H NMR and ^13C NMR spectra.The final compounds were confirmed by ^1H NMR,^13C NMR and HRMS techniques,and the results are consistent with the reported natural products.