中文摘要：

变形链球菌是口腔内的重要致龋菌之一,也被证明与许多全身系统性疾病有密切的关系。细胞外蛋白往往含有致病或毒性因子,其与疾病发病机制密切相关,对病理研究和抗生素开发等也具有重要意义。多种高通量的组学技术在变链菌的研究中被广泛应用。其主要是通过基因芯片和转录组测序检测相关基因的转录水平,同时也通过蛋白质组学技术来研究变形链球菌的致病特性。本文将系统介绍蛋白质组学在变形链球菌致病性研究中的应用。

英文摘要：

Extracellular proteins, always contain pathogenic or toxic factors, are closely related to the pathogenesis of the disease. A variety of high-throughput omics technology are widely used in the study of Streptococcus mutans. For example gene chip and transcriptome sequencing were used to detect the transcription level of the related gene. Meanwhile proteomic technology were also used to study the pathogenic characteristics of streptococcus mutans. The paper will introduce the application of proteomics in Streptococcus mutans pathogenic research