中文摘要：

目的探讨新疆喀什地区伽师县克孜勒博依乡维吾尔族妇女人群 HPV （Human papilloma virus ，人乳头瘤病毒）感染情况及 HPV感染与不同程度宫颈病变的关系，为制定新疆农村妇女宫颈癌防治对策和措施提供科学依据。方法于2011年6月15日-7月15日在伽师县克孜勒博依乡选择30～60岁的1300例维吾尔族妇女为主要研究对象。所有研究对象接受问卷调查、妇检、HPV-DNA检测（HC-Ⅱ）、液基细胞学检查，对于 HPV-DNA检测（HC-Ⅱ）与液基细胞学检查任意一项阳性者行阴道镜下宫颈活组织检查。结果（1）喀什地区伽师县克孜勒博依乡妇女 H PV总阳性率为10．31％。宫颈液基细胞异常率为2．77％。（2）不同宫颈病变脱落细胞中 H PV DNA 负荷量中位数最高为宫颈癌，最低为慢性宫颈炎，慢性宫颈炎组与CIN组及宫颈癌组比较，差异有统计学意义（P ＜0．05）；CIN各组和宫颈癌组之间比较差异无统计学意义（P ＞0．05）。（3）HPV感染组中，细胞学阳性率分别为：ASCUS 42．11％、ASC-H 50％、LSIL 66．7％、HSIL 66．7％、浸润癌100％，与 HPV非感染组阳性率比较差异有统计学意义（P ＜0．05）；随着宫颈病变程度的加重，HPV阳性率也逐渐升高，且在各种宫颈细胞学病例中HPV感染的阳性率差异有统计学意义（P＜0．05）。结论 HPV感染率与宫颈病变严重程度有关；宫颈细胞学异常与H PV感染有关；高病毒负荷量可能比患宫颈癌及宫颈上皮内瘤变的风险更大，但是不能用来预测宫颈病变的严重程度。

英文摘要：

Objective By investigating the infection of human papillomavirus （HPV ） and distribution of HPV subtypes in population ,and the relation between HPV infections with squamous intraepithelial lesion in the Kizilbuy village in Kashgar Xinjiang ,provides a scientific basis for the development of cervical canc-er prevention strategies and measures .Methods A population based cervical cancer screening was done from June15 to July 15 ,2011 ,among 1 ,300 women in Kizilbuy township of Payzawat ,Kashgar ,Xinjiang ranging in age from 30 to 60 .And all of the objectives were carried through questionnaire performing , HPV-DNA testing ,liquid-based Cytology the patient who had positive for the HPV-DNA testing and liq-uid-based cytology was put up colposcopic biopsy .Results （1） 134（10 .31% ） women in all were HPV positive ,diagnosis ≥ASCUS by liquid-based cytology was 2 .77% （36/1 ,300） .（2） In different cervical le-sions ,the highest median load shedding of HPV is cervical cancer ,and the lowest is chronic cervicitis . When Chronic cervicitis group compared with the CIN group ,the difference was statistically significant （P〈0 .05）;Comparison between the CIN group and cervical cancer group was not statistically significant （P〉0 .05） .（3） In HPV infected group ,positive ratio of cytologic test was 42 .11% in ASCUS ,50% in ASC-H ,66 .7% in LSIL ,66 .7% in HSIL and 100% in Invasive carcinoma .There was a statistically sig-nificance in this group .Conclusion The positive rate of HPV related to the severity of cervical disease , the positive rate of cytology related to HPV positivity ;High viral load is likely to suffer a greater risk of cervical cancer and cervical intraepithelial neoplasia ,but can not be used to predict the severity of cervical lesions .