中文摘要：

目的探讨DC-CIK细胞治疗恶性肿瘤后出现不良反应,发热症状,探究感染因素,以指导临床用药和护理工作。方法通过40例患者接受DC-CIK细胞,采集方法、皮下注射与输注治疗后,其中10例患者出现发热症状时的体温、外周血像、血培养的结果比较,从而探讨患者是否存在感染。结果 40例患者中体温正常30例,血像正常,细菌培养未发现致病菌;10例发热患者中体温〈39℃8例,白细胞（2.8～5.27）×109/L,体温〉39℃2例;白细胞（1.5～2.5）×109/L;细菌培养致病菌阳性4例,检出病原菌为酿脓链球菌、金黄色葡萄球菌、肺炎克雷伯菌和光滑假丝酵母菌。结论接受DC-CIK细胞治疗的肿瘤患者中,有部分患者发热,发热虽然是人体的一种不良反应,也要时刻注意感染的威胁。

英文摘要：

OBJECTIVE To explore the related factors for the infections in the tumor patients who had suffered from adverse reactions such as fever after the DC and CIK therapy.METHODS A total of 40patients accepted the DC anc CIK therapy after peripheral blood collection subcutaneous injection and vein infusion,we compared the temperature,the WBC counts and blood culture results of 10patients who suffered from fever after above therapy,and further explored if the infections occurred.RESULTS Of totally 40patients,there were 30cases with the body temperature lower than 36.5℃and normal hemogram,and the bacterial culture found no strains of pathogens;of 10fever patients,there were 8cases with the body temperature lower than39℃,the WBC counts varying from 2.8×109/L to 5.27×109/L and 2cases with the body temperature higher than 39℃,the WBC counts varying from 1.5×109/L to 2.5×109/L;the bacterial culture indicated that there were 4cases with the pathogens tested positive,the pathogens included Streptococcus pyogenes,Staphylococcus aureus,Klebsiella pneumoniae and Candida glabrata.CONCLUSION Some of the tumor patients who had accepted DC and CIK therapy suffered from the fever.Although fever is one kind of adverse reactions,we should pay more attention to the infections.