欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
以取代靛红作为起始原料,通过和芝麻酚在10 mol%DABCO催化剂和二氯甲烷溶剂条件下的Aldol反应,高效合成3个未见文献报道的3-（5-芝麻酚）-3-羟基氧化吲哚（2a～2c）,产率为85%-92%。以取代靛红作为起始原料,通过和芝麻酚以及丙二腈在10 mol%DABCO催化剂和二氯甲烷溶剂条件下的三组分Domino反应,高效合成5个未见文献报道的芝麻酚并吡喃螺环氧化吲哚（3a-3e）,产率为87%-94%。底物取代基结构经1H NMR,13C NMR和MS（ESI）表征。
英文摘要：
Sesamol and various substituted isatins were catalyzed by 10 mol% DABCO in CH2Cl2 at room temperature via Aldol reaction. Three unreported 3-（5-sesamol）-3-hydroxyoxindoles（2a - 2c） were obtained with yields of 85% - 92%. Sesamol,malononitrile and various substituted isatins were catalyzed by DABCO in CH2Cl2 at room temperature via Domino reaction. Five unreported spiro-fused pyranyl benzo[d][1,3]dioxol oxindoles（3a - 3e） were synthesized efficiently with yields of 87% - 94%. In this paper we also discussed the relationship between reaction rate and substituent groups in such reactions. The structures of substituent group of substrates were characterized by1 H NMR,13 C NMR and MS（ESI）.
同期刊论文项目
同项目期刊论文
期刊信息
位置：