中文摘要：

Wnt/β-catenin信号通路作为一条进化保守的信号通路,有着广泛的生物学作用。研究发现,Wnt/β-catenin信号通路与干细胞衰老之间存在联系。激活Wnt/β-catenin信号通路可导致干细胞发生衰老变化,而抑制Wnt/β-catenin信号通路可延缓干细胞的衰老。本文对Wnt/β-catenin信号通路与干细胞衰老之间的关系及其作用机制作一综述。

英文摘要：

The Wnt/β-catenin signaling is an evolutionarily conserved signaling pathway which has extensively biological function.Recent researches suggest that the Wnt/β-catenin signaling influences stem cell aging.The Wnt/β-catenin signaling may accelerate the aging of stem cell,and the age-related changes in stem cell may be delayed by altering the Wnt/β-catenin signaling directly.This review focused on the relationship between the Wnt/β-catenin signaling and stem cell aging and the mechanism of the Wnt/β-catenin signaling promoting stem cell aging.