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Molecular logic computing model based on DNA self-assembly strand branch migration
  • ISSN号：1001-6538
  • 期刊名称：Chinese Science Bulletin
  • 时间：2012.10.23
  • 页码：2909-2915
  • 分类：TP38[自动化与计算机技术—计算机系统结构;自动化与计算机技术—计算机科学与技术] TP18[自动化与计算机技术—控制科学与工程;自动化与计算机技术—控制理论与控制工程]
  • 作者机构：[1]Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University, Beijing 100871, China, [2]College of Life Science Shaanxi Normal University, Xi'an 710062, China, [3]School of Control and Computer Engineering, North China Electric' Power University, Beijing 102206, China
  • 相关基金：This work was supported by the National Natural Science Foundation of China （61127005, 61133010, 61033003, 60910002 and 61143003）, Ph.D. Programs Foundation of the Ministry of Education of China （20110001130016）, and the Postdoctoral Special and Normal Science Foundation of China （201104018, 20100480128, 2011M500197）.
  • 相关项目：基于细胞（膜和核酸）的计算模型和算法研究
作者： Cheng Zhang|Lina Ma|Yafei Dong|Jing Yang|Jin Xu|
关键词： DNA链, 运算模型, 自组装, 逻辑, 迁移, 输入信号, 分子, 凝胶电泳, DNA strand branch migration, DNA self-assembly, molecular logic computing, molecular intelligence, modularized design
中文摘要：

在这研究， DNA 逻辑计算模型基于自己组装的 DNA 和海滨分支移植的方法被建立。由增加信号海滨，预编程的信号与起始的集会结构瓦解被释放。然后，计算结果能被胶化电气泳动检测。整个进程自动地被控制并且 parallely，甚至由输入信号的混合被触发。另外，极、双极的单身者的概念被介绍进系统设计，它导致同步和模块化。认出特定的信号 DNA 搁浅，计算模型由胶化实验给所有正确结果。

英文摘要：

In this study, the DNA logic computing model is established based on the methods of DNA self-assembly and strand branch migration. By adding the signal strands, the preprogrammed signals are released with the disintegrating of initial assembly structures Then, the computing results are able to be detected by gel electrophoresis. The whole process is controlled automatically and parallely, even triggered by the mixture of input signals. In addition, the conception of single polar and bipolar is introduced into system designing, which leads to synchronization and modularization. Recognizing the specific signal DNA strands, the computing model gives all correct results by gel experiment.

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