外周血单个核细胞中存在一些独特的祖细胞群体,包括造血干细胞、血管内皮祖细胞(EPC)、间充质干细胞、循环纤维细胞(fibrocytes)等,这些细胞因能在适宜条件下分化为具有不同功能的成熟细胞,长期受到研究者们关注。近年来,研究者发现一种来源于外周血的干/祖细胞——单个核细胞来源的多潜能细胞(MOMC),其具有可从外周血获取并体外扩增、表型独特和多向分化的特性,
Mononuclear cell -derived multipotential cell (MOMC)is a unique cell population that derived from circulating CD14 + mononuclear cell, with phenotypic characteristics of CD14 + , CD45 + , CD34 + , as well as type I collagen. It can be induced to differentiate into a wide range of mesenchymal lineages, including endothelium-like cells, myocardium-like cells, neuron-like cells, osteoid cells, chondroid cells, lipoid cells, myoid cells, epidermoid cells, and hepatoid cells. More strikingly, MOMC is easy to be obtained, and it can expand easily in vitro, which can be transplantated autologously without ethical limitations. MOMC is an ideal source of cell therapy for tissue regeneration and wound repair.