中文摘要：

目的探讨加巴喷丁的镇吐作用及可能的作用机制。方法60例ASAⅠ～Ⅱ级行择期腹腔镜胆囊切除术患者,随机分为两组：对照组（C组）。行常规气管插管吸入全身麻醉,加巴喷丁组（G组）术前1h口服加巴喷丁600mg,加巴喷丁组诱导插管麻醉维持同C组。分别测定服药前（基础值）、服药后1h、手术结束时,术后4h,术毕后24h血浆P物质的水平,观察术后24h恶心呕吐程度及发生率。结果C组30例中有19例发生恶心、呕吐,发生率为63.3%,G组为10例,发生率分别为33.3%。围术期血浆P物质的水平：C组术毕明显高于基础值（P〈0.05）,术后4h,24hG组明显低于C组（P〈0.05）。结论术前1h口服加巴喷丁600mg能降低腹腔镜胆囊切除术后恶心呕吐发生率,可能与抑制血浆P物质的合成及分泌有关。

英文摘要：

[Objective] To explore the antiemetic mechanism of gabapentin in patients subjected to laparoscopic cholecystectomy under general anesthesia. [Methods] Sixty ASA Ⅰ-Ⅱ patients of either sex undergoing elective laporoscopic eholecystectomy were randomly assigned to two groups： control group （group C） and gabapentin group （group G）. Patients adopted general anesthesia and were intubated. In group G gabapentin 600 mg was given orally 1 h before induction of anesthesia. The induction and maintenance were standardized in both groups. The plasma concentrations of substance P were measured at the time before medication （T1）, 1 hour after medication （T2）, at 0, 4^th, 24^th hour （T3, T4, T5） after operation. Postoperative nausea and vomiting （PONV） were assessed. [Results] The incidence of PONV was significantly lower in group G （33.3%, 10/30） than that in group C （63.3 %, 19/30）. In group C the plasma level of substance P at T3 was significantly higher than at T1 （P 〈0.05）. The plasma concentrations of substance P at T4, T5 in group G were significantly lower than those in group C （P 〈0.05）. [Conclusions] Preoperative administration of 600 mg gabapentin can greatly reduce the incidence of PONV after laparoscopic cholecystectomy. Inhibition of synthesis and secretion of substance P may be the mechanism.