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中文摘要：
为研究双氟沙星（Difloxacin,DIF）在草鱼（Ctenopharynodon idellus）体内的药代动力学以及在各组织中的残留量,采用高效液相色谱法测定在15℃水温状态下单次给草鱼灌喂20 mg/kg剂量的双氟沙星后,得出双氟沙星在各组织以及血液中的药时曲线均都符合二室开放性模型,双氟沙星能够在草鱼体内快速吸收,并且血液及各组织中均有分布,双氟沙星在草鱼体内的药物动力学方程为C=5.056e^–0.012t＋19.041e^–0.011t,其中双氟沙星在血液、肌肉、肝脏、肾脏中吸收半衰期（T1/2α）分别为0.176h、0.562h、4.562h和1.477h,消除半衰期分别为（T1/2β）69.492h、65.303h、218.412h和163.937h,总体消除率（CL）分别为0.495、11.181、10.789和7.102 L/（h·kg）,药时曲线下面积（AUC）分别为81.550、1277.55、807.470和1432.150μg/（L·h）。根据相关规定肌肉中双氟沙星最大残留量300μg/kg为标准,建议休药期26d以上。
英文摘要：
This paper studied the pharmacokinetics of difloxac（DIF） in grass carps（Ctenopharyngodon idellus） following a single 20 mg/kg oral dose at 15. The concentrations of DIF in blood and tissues（muscle, liver, and kidney） were detected by HPLC. The parameters were analyzed based on the classical compartmental analysis. The results showed that the DIF were rapidly absorbed by the grass carp and widely distributed in the blood and tissues. The drug concentration-time curves of DIF in blood and tissues all were best described by a two compartment-open model. And the best concentration-time equation of blood was C=5.056e^–0.012t＋19.041e^–0.011 t. In addition, the absorption half-life（T1/2α） of DIF in the blood, muscle, liver and kidney were 0.176 h, 0.562 h, 4.562 h, and 1.477 h, respectively. The elimination halflife（T1/2β） of DIF in the corresponding tissues were 69.492 h, 65.303 h, 218.412 h, and 163.937 h, respectively. The body clearances（CL） in the corresponding tissues were 0.495, 11.181, 10.789, and 7.102 L/h/kg, respectively. The corresponding areas under the curves（AUC） were 81.550, 1277.55, 807.470 and 1432.150 μg/L/h, respectively. What＇s more,the recommended withdrawal period of DIF was more than 26 days under the standard of not more than 100 μg/kg residual amount in the edible tissues.
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