中文摘要：

Clindamycin 磷酸盐(CP ) ，一个抗菌剂代理人，被报导了形成几固态形式。二 CP solvates， dimethyl sulfoxide (DMSO ) solvate 和甲醇 / 水 solvate (solvate V ) 的水晶结构，被单个水晶 X 光检查衍射决定了。这些形式的性质和转变被粉末 X 光检查衍射，单个水晶的 X 光检查衍射，微分扫描热量测定， thermo gravimetric 分析，热阶段的显微镜学，和动态蒸汽吸着描绘。很不同的氢结合网络在二晶体结构在主人主人和主人溶剂分子之中存在，导致不同潮湿稳定性。在加热和 desolvation 之上的二 solvates 的热稳定性也被学习。当温度在甲醇的沸腾的点上面时， solvate V 在一个步 desolvation 过程以后变换成一个多态的阶段，而 DMSO solvate 的 desolvation 温度在 DMSO 的沸腾的点下面。在超过 43% 的相对湿度， DMSO solvate 在 25 离子转变了到水合物流动在壳附近。在先，鳍角度被修理到零度，当时？？

英文摘要：

Clindamycin phosphate （CP）, an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide （DMSO） solvate and a methanol/water solvate （solvate V）, have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 ℃. In contrast, solvate V did not transform at any of the humidities studied.