此文报道了由酰肼,二硫化碳及卤代烃或α,β-不饱羰基化合物在水相中——锅煮反应合成1,3,4-噁二唑-5-硫醚类化合物的方法。该方法具有高效、反应条件温和、操作简单、适用范围广和环境友好等优点。
An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5- thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or α, β-unsaturated carbonyl compounds. The reactions were carried out in water in the presence of potassium phosphate within 2-4 h to afford the expected products in excellent yields.