中文摘要：

通过1型和2型糖尿病动物模型的研究，发现过渡金属元素钒（V）具有降糖作用．有机钒化合物与无机钒相比，其副作用低、体内吸收率和生物利用度高．主要探讨了4价有机钒化合物4-氯-2，6-双吡啶双氧钒化合物（4-chloro-2，6-dipicolinatodioxovanadium（IV），v4dipic—C1）对链脲佐菌素（STZ，55mg／kg）诱导的1型糖尿病大鼠的生物学作用．大鼠通过自由饮水的方式口服V4dipic-Cl（o．5mg／mL）8天．结果表明，V4dipic—C1组的大鼠血糖和血清碱性磷酸酶（ALP）活性显著低于糖尿病对照组，并且其葡萄糖耐量水平得到明显改善．但有机配体H2dipic—Cl对糖尿病大鼠的血糖和血清ALP活性的影响不显著．结果提示V4dipic-Cl具有降低糖尿病大鼠的血糖，提高葡萄糖耐量和改善肝功能的作用．

英文摘要：

The insulin-mimic effect of vanadium compounds has been widely reported in both type 1 and 2 diabetes animal models. Recently, various organic vanadium compounds have been synthesized to lower the side effect of inorganic vanadium and improve its poor absorption efficiency. In the present study, we evaluated the biological effects of V4dipic-Cl in streptozotocin （STZ）-induced diabetic rats. V4dipic-Cl was orally administrated to diabetic rats for eight days at the dose of 0.5mg/mL through drinking water. The blood glucose level, serum alkaline phosphorase （ALP）, aspartate amino transferase （AST） and blood urea nitrogen （BUN） were determined. In addition, an oral glucose tolerance test was carried out. The results showed that blood glucose, serum ALP, AST and BUN were significantly increased in STZ induced-diabetic rats. The level of glucose tolerance in diabetic rats was lower than that in the controls. At the end of the experiment, blood glucose and serum ALP in Vadipic-Cl- treated diabetic rats were significantly decreased. Meanwhile, oral glucose tolerance of diabetic rats was improved as compared to the H2dipic-Cl-treated diabetic rats. In conclusion, it was found that V4dipic-Cl could decrease blood glucose level and restore the hyperglycemia-induced hepatic dysfunction in STZ-induced diabetic rats.