中文摘要：

TORC1（target of rapamycin complex 1）可整合营养、能量、生长因子及氨基酸等多种细胞外信号,调控基因转录、蛋白质翻译、核糖体合成等生物过程,在细胞生长和凋亡中发挥极为重要的作用。亮氨酰-tRNA合成酶（LeuRS）的经典功能是催化合成亮氨酰-tRNA直接参与遗传信息的解码合成蛋白质。最新研究结果表明人细胞质LeuRS除了经典功能外,还参与调控TORC1途径。综述了LeuRS的非经典功能,它是如何通过感受细胞内的亮氨酸浓度来调节TORC1活性的。这些结果表明了古老的氨基酰-tRNA合成酶家族在进化的过程中被赋予了新的功能。

英文摘要：

TORC1 regulates translation and cell growth in response to a variety of signals,including hormones,growth factors,energy levels,and amino acids such as leucine.The dysregulation of TORC1 pathway is associated with several hamartoma syndromes and cancers.Leucyl-tRNA synthetase（LeuRS） catalyzes the formation of LeutRNA for decoding the genetic information.Recent works reveal that the pathway for leucine signaling to TORC1 is mediated by LeuRS,which functions as a sensor for intracellular leucine.These results show that an old family of aminoacyl-tRNA synthetases is conferred new function during the evolution.