中文摘要：

1目的调查胃癌患者直系亲属幽门螺杆菌（Hp）感染情况，为有效预防控制Hp感染提供依据。方法选择我院收治的46例已确诊胃癌患者的直系亲属139例进行调查，采用描述性研究方法进行分析。采用’4c呼气试验检查Hp，并对Hp阳性者进行血清学Hp分型检查。结果胃癌患者直系亲属Hp感染率为77．70％。男性感染率为78．79％，女性感染率为76．71％，男女感染率差异无统计学意义（P〉0．05）。45～59岁年龄组Hp感染率最高，达92．30％，30～〈45岁和45～59岁年龄组与〈15年龄组比较Hp感染率差异有统计学意义（P：0．003、0．015）；年龄与Hp感染率高度相关（r=0．884）。亲缘关系以配偶感染率最高，达91．11％，配偶与子女Hp感染率比较，差异有统计学意义（P=0．002）。Hp感染中以Hp-1型为主，占70．37％，与Hp-2型比较，差异有统计学意义（P〈0．01）。结论胃癌患者直系亲属的幽门螺杆菌感染率高，以致病力强的Hp-1型为主。

英文摘要：

Objective To investigate the heli cobacter pylori （Hp） infection in immediate relatives of patients with gastric cancer, in order to provide scientific evidence for infection control. Methods Descriptive statistic method was applied to analyze the 139 immediate relatives of 46 patients diagnosed with gastric cancers. 14C urea breath tests was performed for Hp detection, and serological typing was further performed for those with Hp-positive results. Results The Hp infection rate of the immediate relatives of patients with gastric cancer was 77.70%. The Hp infection rate a- mong male was 78.79%, and which was 76.71% among female. The Hp infection rates between genders were not found significant difference. The infection rate in the group aged 45-54 was the highest, which was 92.30%, the significant differences in Hp infection were found between the group aged 30-〈45 or 45-59 and the group aged 〈 15 （P = 0.003, 0.015）. The high correlation was found between age and Hp infection rate （r = 0.884）. Among different genetic relation ships, the infection rate in the spouses of patients with gastric cancer was the highest, which was 91.11%. The significant difference in Hp infection between spouse and children of patients with gastric cancer was found （P = 0.002）. The main serological Hp type was Hp-1, occupied 70.37%, compared with Hp-2, the difference was significant （P 〈 0.01）. Conclusion The Hp infection rate is high in immediate relatives of patients with gastric cancer, and the predominant serological type of Hp is HO-1.