中文摘要：

目的 应用3.0T高场磁共振3D-TOF序列对抑郁症模型大鼠的大脑中动脉血管进行研究,明确大脑中动脉血管在抑郁模型大鼠中的变化.方法 将40只SD大鼠随机分为对照组和抑郁组,每组20只.对照组不处理,抑郁组按制备抑郁模型处理.分别于0,4,6,8周对其进行MR扫描,并采用Mimics软件进行血管勾画.对比分析大脑中动脉直径及长度变化及与建立抑郁大鼠模型时间关系.结果 与对照组相比,随着抑郁模型应激周数的增加,抑郁组大鼠大脑中动脉相应发生改变,即于第4周发生管径显著变细[左侧直径：对照组（0.31±0.05）mm,抑郁组（0.28±0.04） mm,t=2.76,P＜0.05;右侧直径：对照组（0.30±0.05） mm,抑郁组（0.27±0.03） mm,t=2.61,P＜0.05],第6周长度显著减少[左侧长度：对照组（5.6±0.77）mm,抑郁组（4.9±0.73） mm,t=2.84,P＜0.05;右侧长度：对照组（5.5±0.76） mm,抑郁组（4.8±0.72） mm,t=3.11,P＜0.05],第8周管径与长度较对照组均发生更为显著改变[左侧直径：对照组（0.31±0.05） mm,抑郁组（0.22±0.02） mm,t=5.50,P＜0.01;右侧直径：对照组（0.30±0.04） mm,抑郁组（0.21±0.02） mm,t=5.57,P＜0.01;左侧长度：对照组（5.6±0.78） mm,抑郁组（4.3±0.70） mm,t=5.49,P＜0.01;右侧长度：对照组（5.5±0.79） mm,抑郁组（4.2±0.71） mm,t=5.45,P＜0.01].结论 抑郁大鼠大脑中动脉的改变一定程度揭示了其脑血管和抑郁症疾病之间的关系.

英文摘要：

Objective To investigate the variation of middle cerebral arteries of rats in depression model by using 3D-TOF sequence on 3.0T MR.Methods Forty SD rats were randomly divided into control group and depressive group with 20 in each.Compared with control group,depressive group were handled according to the demand of rat depression model.Rats were scanned by 3.0T MR on 0th,4th,6th,8th week respectively.Using Mimics software,the variation of middle cerebral arteries were described and analysed.Results Compared with the control group,the middle cerebral arteries of depressive group rats changed along with the increase of time.On the 4th week,the diameter of the middle cerebral arteries of rats decreased significantly （the diameter of left middle cerebral arteries：control group （0.31 ±0.05） mm,depressive group （0.28±0.04） mm,t=2.76,P〈0.05 ; the diameter of right middle cerebral arteries：control group （0.30 ± 0.05） mm,depressive group （0.27± 0.03） mm,t =2.61,P〈 0.05）.On the 6th week,the length of the middle cerebral arteries of rats decreased significantly （the length of left middle cerebral arteries：control group （5.6± 0.77） mm,depressive group （4.9 ± 0.73） mm,t =2.84,P〈 0.05 ; the length of right middle cerebral arteries：control group（5.5±0.76） mm,depressive group（4.8±0.72） mm,t=3.11,P 〈0.05）.On the 8th week,the diameter and length of the middle cerebral arteries of rats decreased more significantly （the diameter of left middle cerebral arteries：control group （0.31 ±0.05） mm,depressive group （0.22±0.02） mm,t =5.50,P〈 0.01 ; the diameter of right middle cerebral arteries：control group （0.30 ± 0.04） mm,depressive group （0.21 ±0.02） mm,t=5.57,P〈0.01 ; the length of left middle cerebral arteries：control group （5.6±0.78） mm,depressive group （4.3±0.70）mm,t=5.49,P〈0.01 ;the length of right middle cerebral arteries：control group （5.5 ± 0.79） mm,depressive group （4.2±0.71）mm,t=5.45,P〈0.01）.Conclusion The