中文摘要：

目的研究益气活血法对血瘀证心肌缺血再灌注损伤（IRI）兔血液流变性及内皮素的影响，以探讨其对心肌IRI保护作用机制。方法家兔随机分为空白组、血瘀证组、IRI组、预处理组、丹参组和加味丹参饮组，建立血瘀证兔IRI模型，以益气活血的加味丹参饮对该模型进行干预，检测血液流变性和血浆内皮素～1（ET-1）水平变化。结果IRI组各项血液流变学指标及血浆ET-1水平均显著增高，与空白组比较差异具有统计学意义；而加味丹参饮组血液流变学指标及血浆ET-1水平降低，与IRI组比较差异有统计学意义。结论益气活血法可以改善IRI兔的血液流变学状态，调节血管内皮功能，可能为其保护IRI心肌作用机制之一。

英文摘要：

Objective： To study the effect of tonifying qi and activating blood method on blood rheology and en- dothelin in blood stasis syndrome （BSS）rabbits with myocardial ischemia reperfusion injury （IRI） and to explore its protective mechanism in cardiac muscle of IRI rabbits. Methods： Rabbits were divided randomly into： the control group, the BSS group, the IRI group, the precondition group, the Danshen group and the modified Danshen Decoction group. The iRI model rabbits of BSS was intervened with modified Danshen Decoction. And then, indices of hemorheology and plasma endothelin- I（ET -1 ） were measured in rabbits. Results： Compared with the control group, the level of ET - 1 and the indices of blood theology were significantly increased in IRI group. These indices in modified Danshen Decoction were decreased obviously compared with the IRI group. Conclusion： Tonifying qi and activating blood method could improve the blood rheology condition and regulate the endothlin condition. These would be one of the mechanisms of protecting cardiac muscle of IRI rabbits.