中文摘要：

目的：评估前列腺特异抗原密度（prostate specific antigen density,PASD）对前列腺癌根治术后不良病理结果的预测价值。方法：回顾性分析50例病理确诊为前列腺癌患者的临床资料,收集患者术前总前列腺特异抗原（total prostate specific antigen,tPSA）、PSAD及穿刺活检Gleason评分结果,比较在手术切缘阳性（positive surgical margins,PSM）、前列腺包膜外侵犯（extracapsular prostatic extension,EPE）、精囊入侵（seminal vesicle invasion,SVI）患者中以上各项指标的差异,对有统计学差异的因素行多元Logistic回归分析,筛选影响浸润的最主要因素,同时运用工作特征曲线（ROC曲线）比较各指标的预测价值。结果：PSM,EPE和SVI患者之间PSAD存在统计学差异,PSAD曲线下面积高于PSA与Gleason评分。多元Logistic回归分析结果表明,PSAD和Gleason评分对PSM和EPE有着统计学意义的预测价值,且PSAD和PSA与SVI有关。结论：PSAD可作为接受前列腺癌根治术的患者术后不良的预测指标。

英文摘要：

Objective： To evaluate the value in prostate cancer prognosis by determining the predictive potential of prostate-specific antigen density density（PSAD）for adverse pathologic features after radical prostatectomy.Methods： We retrospectively analysed 50 patients diagnosed with prostate cancer and underwent a retropubic radical prostatectomy for clinically localized disease.Data concerning preoperative PSA,biopsy Gleason score and PSA density were collected and analyzed.We respectively compared difference of the above parameters in positive surgical margins（PSM）,extracapsular prostatic extension（EPE）,seminal vesicle invasion（SVI） and the statistically different factors line multivariate logistic regression analysis,which filter out the most important of impact of infiltration,and appraised the value of each of the parameters in predict value with a relative operating characteristic（ROC） curve.Results： There was a significant difference in PSA density values between patients with PSM,EPE,SVI.Areas under the curve for PSA density were higher than those of PSA and Gleason score for all parameters of adverse pathology.In multivariate analyses,it was shown that PSA density and Gleason score were the only statistically significant predictors for PSM and EPE,PSA density and PSA for SVI.Conclusion： PSA density is an accurate predictor for adverse pathology prediction in patients undergoing radical prostatectomy.