中文摘要：

通过调整制备过程中的搅拌速度合成了具有不同二次孔结构的双模型介孔SiO2纳米材料（BMMs）,进而通过3-（2-氨基乙基氨基）丙基三甲氧基硅烷对其表面修饰,以布洛芬为模型药物,重点考察了组装与缓释性能,并根据Korsmeyer–Peppas方程分析其释放动力学行为.采用XRD、TEM、N2吸脱附曲线以及元素分析等多种表征手段,结果表明通过改变搅拌速度可以改变正硅酸乙酯的水解和缩聚速度,从而直接影响BMMs一级孔结构的有序度和由颗粒堆积而成的二级孔大小.选用布洛芬作为药物模型,BMMs一级孔结构主要影响其药物的组装性能,二级孔结构则主要影响药物分子的缓释行为,二级孔越大,释放速率越快.

英文摘要：

Three kinds of bimodal mesopores silica-based nanomaterials（BMMs） with different accumulated pores structure were synthesized by tuning the stirring rate in the preparation process and then functionalized with silane coupling agent 3-（2-aminoethylamino） propyltrimethoxysilane（NN-TES）.The modified BMMs were used as ibupro-fen carriers and their delivery property were studied with Korsmeyer-Peppas model.With the help of XRD,TEM,N2 adsorption and desorption isotherms and elemental analysis,it indicated that the hydrolysis and condensation polym-erization rate of TEOS would be influenced by changing the stirring rate,which resulted in the formation of three kinds of BMMs with different small pores order and large accumulated pores structure.When applying NN-TES modified BMMs as ibuprofen carriers,the ibuprofen loading amount in three different kinds of BMMs were almost the same,while the release rate had great difference from each other.These results demonstrate that the drug loading ca-pacity was affected by the small pores of BMMs,while the large pores of BMMs would influence the drug diffusion behaviors in the mesoporous channels,leading to the increase of release rate with the increment of the large pore size.