中文摘要：

在人和非人类的首领之间的近种系发生的关系为人的传染疾病的学习使非人类的首领成为一个不能替代的模型。在这研究，我们带着带传染疾病的中型的实验室动物为使用描述一个大规模自动多功能的隔离房间的发展。包括转移链，消毒链，否定空气压力隔离系统，动物福利系统，和自动化系统，隔离房间被设计满足所有生物安全标准。为了创造完全从外面的、可变频率驱动器被孤立的内部房间环境， blowers 在空气吸入和空气用尽系统被使用，精确控制过滤空气流动并且提供空气障碍保护。一个双门转移港口被用来转移在隔离房间和外面的内部之间的材料。peracetic 酸 sterilizer 和它的联系管道允许隔离房间的完全的消毒。所有能被可编程的计算机化的菜单自动地隔离房间参数控制，允许有在取决于研究工程的不同尺寸的笼子的不同动物的工作。大规模多功能的隔离房间为在高级简历安全实验室带着传染中型的实验室动物工作提供一个有用、安全的系统。

英文摘要：

The close phylogenetic relationship between humans and non-human primates makes non-human primates an irreplaceable model for the study of human infectious diseases. In this study, we describe the development of a large-scale automatic multi-functional isolation chamber for use with medium-sized laboratory animals carrying infectious diseases. The isolation chamber, including the transfer chain, disinfection chain, negative air pressure isolation system, animal welfare system, and the automated system, is designed to meet all biological safety standards To create an internal chamber environment that is completely isolated from the exterior, variable frequency drive blowers are used in the air-intake and air-exhaust system, precisely controlling the filtered air flow and providing an air-barrier protection. A double door transfer port is used to transfer material between the interior of the isolation chamber and the outside. A peracetic acid sterilizer and its associated pipeline allow for complete disinfection of the isolation chamber. All of the isolation chamber parameters can be automatically controlled by a programmable com- puterized menu, allowing for work with different animals in different-sized cages depending on the research project. The large-scale multi-functional isolation chamber provides a useful and safe system for working with infectious medium-sized laboratory animals in high-level bio-safety laboratories.