在茉莉酸(jasmonic acid,JA)信号途径中,植物通过转录激活子和转录抑制子之间的合理协调来调控适当的防御反应及生长发育过程,从而适应多变的环境,以刺激次生产物有效合成,其中b HLH(basic helix-loop-helix)转录因子在响应JA信号诱导植物次生产物萜类合成中起重要调控作用。本文结合植物中b HLH转录因子的结构特点和JA信号在萜类物质合成中的作用,系统地阐述了b HLH转录因子在响应JA信号诱导萜类合成中的调控作用及分子机制,并探讨了b HLH类转录因子与MYB类转录因子互作参与次生代谢调控的过程。本综述为进一步深入揭示b HLH在植物萜类合成代谢调控网络中的分子功能和药用植物活性成分代谢途径的遗传改良提供理论参考。
In jasmonic acid(JA) signaling pathways,the proper defense reaction and the development process of the plant were regulated through transcription activation factor and transcription inhibition factor,in order to adapt to the changing environment and to stimulate synthesis of secondary products. The b HLH transcription factor plays an important role in JA inducing synthesis of terpenoids. Combining with structure characteristics of the b HLH transcription factors and the role of jasmonate-mediated in terpenoids synthesis,the molecular mechanism of b HLH regulated JA-mediated terpenoids synthesis were expound systematically,and interaction of the b HLH transcription factor with MYB transcription factors regulation participated in the process of secondary metabolism were discussed in this paper. This review deeply reveals the molecular function of b HLH in plant terpenes synthesis,and provides theoretical basis of genetic improvement in metabolic pathways of active components from medicine plant.